Dr. Bailey and the gang — but mainly Bailey — will have their hands full in the two-hour Grey's Anatomy Season Five premiere, TV Guide reports.

Why? A trio of gal pals of a certain age descends on Seattle Grace.

In the September 25 episode, Bernadette Peters, Mariette Hartley and Kathy Baker will guest star as friends who each require the hospital's care.

This comes the very same night that Jeffrey Dean Morgan reprises his role of Denny Duquette, although our guess is that is a separate story line.

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