Grey's Anatomy Spoilers: Are Alex and Izzie Done?

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Will Alex and Izzie remain together on Grey's Anatomy?

From previous spoilers (and the impression we get), we feel confident in sticking a fork in Lexie and Mark, at least for the time being. But what about Izzie and Alex?

Katherine Heigl returns to Grey's Anatomy this week in "I Like You So Much Better When You're Naked." But as the sneak peeks show, the reunion is far from joyful.

According to insiders, when it comes to their future, "all bets are off." So basically, no one has any real idea what will happen after Izzie leaves Seattle Grace again.

Izzie is Back

As for Alex's professional life, Arizona may be playing a bigger role. "I finally bring Alex back in the fold," Jessica Capshaw told TV Guide. "Arizona ends up advocating for Alex to find his way in peds and see if he can hack it. He has a very hardcore experience."

The actress who plays Dr. Robbins says she wants to prove working with kids isn't all fluff: "Anyone can operate on brains, but try and operate on baby brains!"

Do you want Alex and Izzie to stay together?

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Grey's Anatomy Quotes

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."

Arizona: Oh my God! I mean, I understand why you're into her. She's hot. Wait, she likes you?
Nathan: What? I mean, I'm going to try not to be offended at that.
Arizona: No, no, no. It's just that Derek was, Derek was epic for her. They were the great love story. I mean, that girl's heart beat for Derek Shepherd. It just, it never occurred to me that she would ever be with anyone else. He was perfect. He was everything. That man turned her world. It, I spooked you. Don't be spooked.