The professional life of Meredith Grey is about to become intertwined with her personal demons.

Following a Grey's Anatomy episode that featured the return of Catherine Avery and a step toward recovery for Arizona, among other developments, this ABC favorite next next Thursday off.

But it then returns on November 8 with "Beautiful Doom," an installment that will find a young woman in serious peril after getting trapped under a car and Meredith desperate to save her life. But is the loss of Lexie clouding this doctor's judgment? Does this case hit too close to painful home?

Watch the official network teaser now and also look forward to Cristina assisting Dr. Thomas on a challenging heart surgery during the hour:

Matt Richenthal is the Editor in Chief of TV Fanatic. Follow him on Twitter and on Google+.