Did the team seriously think their victory in the Framework would signal the end of their pain?
That was addressed on Agents of S.H.I.E.L.D. Season 4 Episode 21, but they were shocked to the core when a dangerous new enemy appeared.
Coulson and Daisy tried to find out the angle this new villain was playing and whether there was any way they could save everyone from it.
Use the video above to watch Agents of S.H.I.EL.D. online to get up to speed with the latest twists in the tale for the characters.
Paul Dailly is the Associate Editor for TV Fanatic. Follow him on Twitter.