Mary Alice: Yes, we may think we're all destined to play certain roles, but sometimes those roles can unexpectedly change: a nervous student may discover a hidden confidence; a long time wife may confront a harsh reality; a busy mother may find her attention needed elsewhere; and a woman who wanted to do a little bit of good may be finding herself playing a much bigger role than she intended.

Yes, we often learn our most important lessons outside the classroom. The painful truth about the state of a relationship, the ugly cost of challenging authority, the sad fact that life's colors aren't always rosy, then are those who refuse to accept these important lessons. They simply wait to teach a lesson of their own.

There are many things that bind friends together - Sharing a laugh over an embarrassing incident, comforting each other in times of need, finding it in our hearts to forgive. But, the thing that binds friends together the most is a secret that changes everything.

A sense of security, it's something we all search for whether it's knowing you're desired, taking control of our fears, or finding strength to do the right thing. But, the danger of a sense of security is that it may prove to be false.

Sometimes it's the little things that make us feel secure, like an old friend at bedtime, money saved for a rainy day, or matching coffee mugs. But, there are times when these small comforts are up against big challenges.

Mary Alice: No matter who we are, we all experience moments of dread. When we ask ourselves: Will anyone believe I'm innocent? Will my daughter be a child of divorce? Will this man break my heart? Are there things that go bump in the night? And sometimes, the answer is yes.

No matter how secure we are, we all experience moments of dread. It may be just before we open our credit card bill or hand over a note to our teacher or step on the scale after a week away from the gym. Yes, we all experience moments of dread. And sometimes, we have no one to blame but ourselves.

People do good deeds for many reasons, but sometimes good deeds have bad consequences. Correcting a colleague's mistake could breed resentment. Opening one's home to a friend can damage that friendship. Trying to bring a spouse closer might push her further away. That's why there's an old expression about helping people - No good deed goes unpunished.

Good deeds aren't always done for the purest of reasons. We may be trying to impress. We may be acting out of guilt. We may be expecting something in return, but occasionally a good deed comes straight from the heart.

The residents of Wisteria Lane are nothing if not loyal. But, there are times when that loyalty is put to the test by the desire to help a stricken friend, by the need to protect a long buried secret, by the movement of two lives in opposite directions. And sometimes just as one test of loyalty ends, another begins.

The residents of Wisteria Lane are nothing if not loyal. They love their country. They root for the home team. They support their favorite brand, but the fiercest loyalty on Wisteria Lane is between friends.

Whenever we make mistakes, we need to apologize and then we need to move on. We must try to accept the changes in our lives or choose to trust an old enemy or learn to stop fighting our children's battles. But, sometimes the pain we caused is so great, there is no moving on.