DEREK: "No, no that is not how this works. How could you know what you know, or suspect it and not even tell me?"
MEREDITH: "You cleared him for surgery, Derek. How did you not know? You can’t be angry with me. She’s my best friend, and right or wrong, she..."
DEREK: "What?"
MEREDITH: "She was there when you weren't."

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Meredith Grey, Derek Shepherd
Grey's Anatomy Season 3 Episode 9: "From a Whisper to a Scream"
Grey's Anatomy
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Grey's Anatomy Season 3 Episode 9 Quotes

DEREK: "Six-letter word for 'pinnacle.'"
MEREDITH: "Zenith."
DEREK: "Ah, this is good. No sex. Crossword puzzles. Current events. When does the knitting start?"
MEREDITH: "Shut up. Good things come to those who wait."
DEREK: "Yeah? I want sex."
MEREDITH: "There will be no sex."

[narrating] "As doctors, we know everybody's secrets. Their medical histories. Sexual histories. Confidential information that is as essential to a surgeon as a ten-blade, and every bit as dangerous. We keep secrets, we have to, but not all secrets can be kept."