Derek: Meredith i am so sorry. Addison...what are you doing here?
Addison: You'd know if you'd bother to answer any one of my phone calls. (turns to Meredith) Hi. I'm Addison Shepherd
Meredith: Shepherd?
Addison: And you must be the woman who's been screwing my husband.

Men don't buy tampons!

George

The game. They say a person either has what it takes to play or they don't. My mother was one of the greats. Me on the other hand. I'm kinda screwed.

Meredith

[narrating] "The thing people forget is how good it can feel when you finally set secrets free. Whether good or bad, at least they're out in the open, like it or not. And once your secrets are out in the open, you don't have to hide behind them anymore. The problem with secrets is even when you think you're in control, you're not."

MEREDITH

DEREK: "Somewhere out there is a steak with your name on it, and maybe a bottle of wine."
MEREDITH: "This is why I keep you around."

[enraged, tackling Alex] "You gave me syphilis!?"

GEORGE

"You are lying. I know you’re lying. You know how I know? Cause you’re a bad liar!"

MIRANDA

CRISTINA: "Okay, I’m in."
MEREDITH: "I am so not involved in this."
CRISTINA: "Meredith, this is Fight Club, nobody talks about it."

PRESTON: "Bill is sterile?"
SURGEON: "And always has been."
GEORGE: "So who got his wife pregnant?"

DEREK: "Maybe we should, you know, make some rules."
MEREDITH: "We should."
DEREK: "Okay."
MEREDITH: "Okay."
DEREK: "Just for the record... I like the glow-in-the-dark ones."
MEREDITH: [laughs] "I bet you do."

MEREDITH: "So just for the record, you’d tell me if I need to get tested, right?"
DEREK: [whispers] "You think I have syphilis?"
MEREDITH: "No, I don't. It's just... I mean we never made any rules or anything... we never said we had rules and I wouldn’t hold it against you."
DEREK: "When would I have time to go out and get syphilis? You’re a handful enough as it is. And besides, we’re practically a condom ad."
MEREDITH: "Yeah...But no more glow-in-the-dark ones."

DEREK: "How goes our special super secret silent sunset surgery?" [pauses] "I've been practicing that."
MIRANDA: "You have too much time on your hands."

Grey's Anatomy Season 1 Quotes

"If I miss a real procedure because of this case, they're gonna call me 007, because I killed you."

CRISTINA

ALEX: "Morning, Dr. Model."
IZZIE: "Dr. Evil Spawn."
ALEX: "Ooooh, nice tat. Do they airbrush that out for the catalogs?"
IZZIE: "I don't know. What do they do for the 666 on your skull?"