10 Key Characters Who Left Grey's Anatomy

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No one is safe on Grey's Anatomy, and we mean no one. Here are 10 main cast members who have left the show.

1. Preston Burke

Preston Burke
Burke and Cristina were just about to be married, but instead, Burke left Cristina at the alter at the end of Season 3. He returned in Season 10 briefly, offering Cristina a job in Zurich.

2. Addison Montgomery

Addison Montgomery
Addison also left in Season 3, heading to Calfornia. She didn't leave us entirely, though, since we were able to enjoy her character more fully on the spin-off, Private Practice.

3. George O'Malley

George O'Malley
The first doctor to be killed off and cause us to cry ugly tears, George was hit by a bus while trying to save another person. His friends all tried to save him, not realizing who he was until he finally was able to communicate his identify by tracing the numbers "007" on Meredith's hand.

4. Izzie Stevens

Izzie Stevens
Izzie overcame cancer and was even re-hired after being fired from the hospital, only to decide to leave Alex and everything else behind.

5. Erica Hahn

Erica Hahn
Erica Hahn just sort of disappeared, last seen heading to her car never to return to the hospital.

6. Lexie Grey

Lexie Grey
Causing even more ugly crying, Lexie Grey was a victim of the plane crash in Season 8. It was completely devestating.

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Grey's Anatomy Quotes

There's a reason I said I'd be happy alone. It wasn't 'cause I thought I'd be happy alone. It was because I thought if I loved someone and then it fell apart, I might not make it. It's easier to be alone, because what if you learn that you need love and you don't have it? What if you like it and lean on it? What if you shape your life around it and then it falls apart? Can you even survive that kind of pain? Losing love is like organ damage. It's like dying. The only difference is death ends. This? It could go on forever.

Meredith

Arizona: Oh my God! I mean, I understand why you're into her. She's hot. Wait, she likes you?
Nathan: What? I mean, I'm going to try not to be offended at that.
Arizona: No, no, no. It's just that Derek was--Derek was epic for her. They were the great love story. I mean, that girl's heart beat for Derek Shepherd. It just...it never occurred to me that she would ever be with anyone else. He was perfect. He was everything. That man turned her world. It...I spooked you. Don't be spooked.