12 Truly Terrible Grey's Anatomy Tragedies

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6. We Have. A Code. Black.

We Have. A Code. Black.
In Season 2, Meredith held a live bazooka shell in her hands - and inside a patient - and as a result, held the lives of everyone in the hospital in the balance. Just when it appeared all would end well after the bombshell episode - pun intended - Kyle Chandler's bomb squad character was turned into pink mist.

5. Denny Duquette Dies

Denny Duquette Dies
The Season 2 finale saw the demise of Denny Duquette (who later returned as a ghost who enjoyed sexual relations with Izzie, which we would prefer not to get into), with far-reaching implications. The charming and tragic patient who won hearts all over the hospital, yet could not keep one beating inside of him, succumbed despite Izzie's best efforts to beat the system and secure a transplant.

4. George O'Malley Dies

George O'Malley Dies
The Samaritan that jumped in front of a bus to save a life at the end of Season 5 and paid for it with his own was not just a random person. John Doe was one of the doctors' own, George O'Malley, who had just joined the army, and even more tragically, the doctors only realized who he was hours later, and could do nothing to save him.

3. The Shooter

The Shooter
Gary Clark, who lost his wife after Derek failed to save her in surgery, decided he needed payback after she was taken off life support ... so he decided to take the doctors' lives, one by one. He brought a gun inside and started shooting anyone and everyone he sees. Reed and Charles die, Alex and Derek are injured Meredith has miscarriage due to the stress. The Season 6 finale was easily one of the most traumatizing episodes of any show ever.

2. The Plane Crash

The Plane Crash
If there's one thing that could top surviving a madman's shooting rampage, it's surviving an actual plane crash, which went down at the end of Season 8. Not that everyone did survive it. Meredith, Derek, Cristina, Arizona, Mark and Lexie all survived, initially, in the woods. Lexie and Mark eventually passed away as a result of their injuries, while Arizona's leg was amputated, Derek's hand was crushed, and everyone was likely scarred for life.

1. Down Goes Derek

Down Goes Derek
They what???? They killed off Derek via an 18-wheeler crashing into him???? Darn you, Shonda.

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Grey's Anatomy Quotes

Arizona: Oh my God! I mean, I understand why you're into her. She's hot. Wait, she likes you?
Nathan: What? I mean, I'm going to try not to be offended at that.
Arizona: No, no, no. It's just that Derek was, Derek was epic for her. They were the great love story. I mean, that girl's heart beat for Derek Shepherd. It just, it never occurred to me that she would ever be with anyone else. He was perfect. He was everything. That man turned her world. It, I spooked you. Don't be spooked.

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."