Octavia and Niylah - The 100
Even though Octavia has had some sketchy plans in the past, Niylah has always stood behind her. To be quite honest, there's no one in the show more loyal to the Red Queen than she is.
Ryn and Maddie - Siren
Ryn and Maddie have a bond that to which no one else can compare. We've got our fingers crossed that they will finally be official when the show returns.
Kara and Lena - Supergirl
There are very few people in the Supergirl fandom that don't see potential between these Kara and Lena. Lena has always been Kara's biggest admirer, and Kara believed in Lena even when no one else did. Honestly, a romance between these two could bring the show to new heights.
Betty and Veronica - Riverdale
We won't accept that the kiss between Betty and Veronica meant nothing. No matter what these besties were trying to prove, there's no denying the obvious sparks between them. And who wouldn't want to see a Beronica and Choni double date?
Meredith and Cristina - Grey's Anatomy
These two actually admitted that they would help each other bury a body. You can't get any closer than that.
Celeste and Madeline - Big Little Lies
Celeste and Madeline are the definition of friendship goals, and there's nothing they wouldn't do for each other. Considering they both have faced challenges in their romantic lives, maybe the solution to their problems is right in front of them.