Daenerys vs. King's Landing - Game of Thrones
Dany had come too far and lost too much to let Cersei hold the Iron Throne for another moment longer. With Drogon enforcing her commands, Dany rained fire down upon King's Landing. Those who survived found themselves with nothing but burns and ashes.
Dr. Campbell vs. Dr. Pemberton - The Big Bang Theory
The slapstick, Sheldon's commentary, and watching Kal Penn and Sean Astin play two longtime friends who viciously betray one another made this lunchtime slugfest into an event worthy of primetime viewing.
Red Daughter vs. Supergirl - Supergirl
Thanks to her evolved powers, Red Daughter had the physical edge. She landed a blow hard enough to stop Supergirl's heart. It takes more than a punch to keep Supergirl down though, especially when the sisterly bond between her and Alex proves it's a force greater than any superpowered being.
Atwater vs. Doyle - Chicago P.D.
While Atwater was undercover a pair of racist cops pulled him over, held a gun to his head, and shot the guy leading him to the drug deal. Then the brass and the politicians pressured him into twisting the facts to benefit their respective agendas. Atwater stuck to the truth and then delivered a well-deserved beatdown to one of the cops.
Betty vs. The Gargoyle King and The Black Hood
Betty Cooper's never-ending reserve of resourcefulness was on full display as she made the Black Hood chase her down the halls of Riverdale High and used anything she could grab as a weapon. As great as the choreography was, witnessing the tragedy of a daughter begging her father not to kill her is what makes this fight riveting.
Captain Anderson and Officer Nolan vs. Southern Front - The Rookie
Southern Front, a white supremacist gang, brought out the guns, cattle prods, and smoke bombs to ambush Captain Anderson and Officer Nolan. They were outgunned and outmanned, but as Anderson said earlier, criminals don't tell LAPD officers what to do. She nearly drowned, broke her thumb, was fatally wounded, and ensured Southern Front couldn't evade the law any longer.