Emma Shuester from Glee
From the getgo, Emma was always adamant about cleaning. Yes, it's her OCD which compulsively drives her to keep everything as spotless as possible, but nonetheless, she loves when everything is clean and working exactly as it should be. Every time Emma cleans, she goes overboard.
Frank Delfino from How to Get Away with Murder
Besides, you know, keeping himself clean, Frank is responsible for a lot of killing and has to tirelessly clean up the areas he's been in, and, also, he's pretty much always cleaning up after one of the Keating Four. He knows how to get away with murder, so Frank knows how to clean to keep yourself and your life free from any kinds of messes.
Felicity Smoak from Arrow
With a husband like Oliver Queen, Felicity must always be cleaning up messes. Pair that with a ten-year-old step child, and, aside from Raisa, I'm sure Felicity is the only one who's ever picking up because she wants to keep her life together as best she can. Ever since she got roped into the Green Arrow mission, Felicity hasn't been able to keep her friends safe, so it's all about controlling what you can.
Ray Palmer from Legends of Tomorrow
Ray seems to be the one to clean up everyone's messes on Legends of Tomorrow. Whether on the ship, which he's basically been designated to keep clean because we never see him out in the field, or during the rare instances where he's allowed to go fight because everyone else screwed up and his suit is too expensive to use outside of rare occasions, Ray Palmer is never done cleaning up after his team.
Brandon Foster from The Fosters
With his girlfriend's health condition, Brandon is pretty much trying to take control of his life wherever he can. While he can't with her, he can by cleaning up his life (figuratively and literally), and making sure there's a nice, safe place to go when it all seems a bit too much.
Clarke Griffin from The 100
After being left on Earth by her family and friends, and presumed dead, Clarke has a lot to clean up in her life. Her relationships are non-existent, broken, and she needs to clean up her space to get rid of radiation, but also clean up her life a bit, too.