Lauren Graham is pretty amazing at playing a mom on TV. She followed her iconic role as Lorelai Gilmore with another fabulous mom role, Sarah Braverman on Parenthood. Now, she's going full circle, and we'll see her as Lorelai Gilmore again on the revival series!
Before Alyson Hannigan was Lily Aldrin on How I Met Your Mother, she was a brainy witch who helped save the world more than a few times on Buffy the Vampire Slayer. As a bonus, How I Met Your Mother gave a few subtle shoutouts to Evil Willow during its run.
Michael J. Fox
Michael J. Fox has graced our TV screens for a long time. We knew him first as Alex on Family Ties, then many years later as Mike Flaherty on Spin City followed by Mike Henry on The Michael J. Fox Show. Most recently, he was Louis Canning on The Good Wife. (And I know, I know. There's also Back to the Future. But we're focused on TV here.)
Before Mayim Bialik played a genuis scientist on The Big Bang Theory (and before she become one in real life) she was unforgettable as Blossom Russo.
David Boreanaz has played two major TV roles on long-running series. We know him now as Seeley Booth on Bones, but years ago, he was a vampire with a soul on Buffy the Vampire Slayer and then its spinoff, Angel.
Alyssa Milano was adorable as Samantha on the classic sitcom, Who's the Boss? She went on to play a very different role as Phoebe Halliwell on Charmed. Most recently, she played another pretty significant role as Savi on ABC's Mistresses.