Coulson and May At Odds - Agents of S.H.I.E.L.D.
Coulson and May spent much of last season at odds. Will she continue as his second in command helping rebuild the team? Or will she refuse to work with powered individuals?
Iain De Caestecker as Agent Leo Fitz - Agents of S.H.I.E.L.D.
Agent Fitz struggled with, but overcame the damage to his brain after suffering oxygen deprivation at the hands of Ward. He was the last person to see Simmons. Will he blame himself for her mysterious disappearance?
Finding Simmons - Agents of S.H.I.E.L.D.
Fitz will not stop until he discovers the truth behind Simmons' disappearance. Can he find some answers regarding the massive alien Kree monolith? Who will he turn to for help, Lady Sif perhaps?
Elizabeth Henstridge as Agent Jemma Simmons - Agents of S.H.I.E.L.D.
As for poor Simmons, is she inside that Kree monolith or did it teleport her elsewhere? Will its unknown properties somehow alter her physically? Perhaps even giving her powers of her own?
Will Simmons Play Nice? - Agents of S.H.I.E.L.D.
Simmons proved to be quite fearful of the Inhumans last season. If/when she reappears, will Simmons play nice with the new superpowered folks? Or will she turn to the ATCU (Advanced Threat Containment Unit) for help?
Henry Simmons as Agent Mack MacKenzie - Agents of S.H.I.E.L.D.
Mack and Coulson definitely clashed last season, as he didn't feel the Director was acting in S.H.I.E.L.D.'s best interest. After saving Coulson's life, their relationship seemed to change for the better.