Patrick Dempsey as Derek Shepherd: A Handsome Tribute

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Rest in peace, Derek Shepherd. And best of luck with what comes next, Patrick Dempsey.

1. Rest in Peace, McDreamy

Rest in Peace, McDreamy
The Derek Shepherd smirk will leave on forever and ever in the hearts and minds of Grey's Anatomy fans.

2. Give Me 10!

Give Me 10!
Derek gets the double high-five request in "Readiness is All."

3. Owen and Der

Owen and Der
Derek and Owen in a photo from "Transplant Wasteland." The episode airs March 14, 2012.

4. Derek: Handsome Fella

Derek: Handsome Fella
Derek looking handsome as ever in a photo from "Transplant Wasteland." The episode airs March 14, 2012.

5. Meredith and Derek in Bed

Meredith and Derek in Bed
Meredith and Derek in bed on Grey's Anatomy!

6. Up Top With Derek!

Up Top With Derek!
Derek shares a double high-five in the May 9, 2013 episode of Grey's Anatomy, "Readiness is All."

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Grey's Anatomy Quotes

There's a reason I said I'd be happy alone. It wasn't 'cause I thought I'd be happy alone. It was because I thought if I loved someone and then it fell apart, I might not make it. It's easier to be alone, because what if you learn that you need love and you don't have it? What if you like it and lean on it? What if you shape your life around it and then it falls apart? Can you even survive that kind of pain? Losing love is like organ damage. It's like dying. The only difference is death ends. This? It could go on forever.

Meredith

Arizona: Oh my God! I mean, I understand why you're into her. She's hot. Wait, she likes you?
Nathan: What? I mean, I'm going to try not to be offended at that.
Arizona: No, no, no. It's just that Derek was--Derek was epic for her. They were the great love story. I mean, that girl's heart beat for Derek Shepherd. It just...it never occurred to me that she would ever be with anyone else. He was perfect. He was everything. That man turned her world. It...I spooked you. Don't be spooked.