Patrick Dempsey as Derek Shepherd: A Handsome Tribute

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Rest in peace, Derek Shepherd. And best of luck with what comes next, Patrick Dempsey.

1. Rest in Peace, McDreamy

Rest in Peace, McDreamy
The Derek Shepherd smirk will leave on forever and ever in the hearts and minds of Grey's Anatomy fans.

2. Give Me 10!

Give Me 10!
Derek gets the double high-five request in "Readiness is All."

3. Owen and Der

Owen and Der
Derek and Owen in a photo from "Transplant Wasteland." The episode airs March 14, 2012.

4. Derek: Handsome Fella

Derek: Handsome Fella
Derek looking handsome as ever in a photo from "Transplant Wasteland." The episode airs March 14, 2012.

5. Meredith and Derek in Bed

Meredith and Derek in Bed
Meredith and Derek in bed on Grey's Anatomy!

6. Up Top With Derek!

Up Top With Derek!
Derek shares a double high-five in the May 9, 2013 episode of Grey's Anatomy, "Readiness is All."

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Grey's Anatomy Quotes

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."

Meredith: You're better than this. You're stronger.
Amelia: Don't make this all your fault. I know you. That's what you do. But, please. Please don't do that.
Maggie: We can't just give up, not after all this time. We have to stand together. We have to fight.
Meredith: Because it's just us now. There were five of us, and now it's just you and I. And it can't be just me. It can't be. I will go down swinging for you, Alex. You know I will. But that means you can't give up. You don't throw the fight. So, whatever you're doing this for... please don't.